Assay Detail
Binding
CHEMBL1764645
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Inhibition of chymotrypsin-like activity of 20S proteasome
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and proteasome inhibition of lithocholic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.21 | 5.72 |
| Inhibition | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760879 | — | — | 1 | 5.72 |
| CHEMBL1760876 | — | — | 1 | 5.66 |
| CHEMBL1760873 | — | — | 1 | 5.46 |
| CHEMBL1760880 | — | — | 1 | 5.42 |
| CHEMBL318779 | — | — | 1 | 5.28 |
| CHEMBL374308 | LACTACYSTIN | — | 1 | 5.25 |
| CHEMBL1760871 | — | — | 1 | 5.24 |
| CHEMBL1760875 | — | — | 1 | 5.16 |
| CHEMBL1760877 | — | — | 1 | 5.07 |
| CHEMBL1760878 | — | — | 1 | 5.07 |
| CHEMBL1760869 | — | — | 1 | 4.99 |
| CHEMBL1760872 | — | — | 1 | 4.97 |
| CHEMBL1760870 | — | — | 1 | 4.94 |
| CHEMBL1478 | LITHOCHOLIC ACID | — | 1 | 4.74 |
| CHEMBL1760874 | — | — | 1 | - |
| CHEMBL1760868 | — | — | 1 | - |
| CHEMBL1760881 | — | — | 1 | - |
| CHEMBL1760882 | — | — | 1 | - |
| CHEMBL1760883 | — | — | 1 | - |
| CHEMBL260735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760879 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1760876 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1760873 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1760880 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL318779 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL374308 | LACTACYSTIN | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1760871 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1760875 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1760877 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1760878 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1760869 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1760872 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL1760870 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL1478 | LITHOCHOLIC ACID | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL1760874 | — | Inhibition | - | % | - | |
| CHEMBL1760868 | — | Inhibition | - | % | - | |
| CHEMBL1760881 | — | Inhibition | - | % | - | |
| CHEMBL1760882 | — | Inhibition | - | % | - | |
| CHEMBL1760883 | — | Inhibition | - | % | - | |
| CHEMBL260735 | — | Inhibition | - | % | - |