Assay Detail
ADMET
CHEMBL1764659
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Antiproliferative activity against human HUVEC cells after 96 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.35 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424278 | O-CHLOROACETYLCARBAMOYLFUMAGILLOL | 2.0 | 1 | 9.12 |
| CHEMBL32838 | FUMAGILLIN | 2.0 | 1 | 8.05 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.52 |
| CHEMBL1761193 | MILTIPOLONE | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424278 | O-CHLOROACETYLCARBAMOYLFUMAGILLOL | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL32838 | FUMAGILLIN | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL1761193 | MILTIPOLONE | IC50 | = | 20000.0 | nM | 4.70 |