Assay Detail
Binding
CHEMBL1764809
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Inhibition of caspase 6 by fluorometric assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.61 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478081 | — | — | 1 | 8.10 |
| CHEMBL1762357 | — | — | 1 | 6.35 |
| CHEMBL1762356 | — | — | 1 | 6.29 |
| CHEMBL1762354 | — | — | 1 | 6.13 |
| CHEMBL1762360 | — | — | 1 | 6.11 |
| CHEMBL1762358 | — | — | 1 | 6.03 |
| CHEMBL1762355 | — | — | 1 | 6.00 |
| CHEMBL1762359 | — | — | 1 | 5.93 |
| CHEMBL1762348 | — | — | 1 | 5.53 |
| CHEMBL1762364 | — | — | 1 | 5.46 |
| CHEMBL456799 | — | — | 1 | 5.35 |
| CHEMBL1762366 | — | — | 1 | 5.33 |
| CHEMBL1762346 | — | — | 1 | 5.31 |
| CHEMBL1762353 | — | — | 1 | 5.16 |
| CHEMBL1762361 | — | — | 1 | 5.16 |
| CHEMBL1762352 | — | — | 1 | 5.12 |
| CHEMBL1762362 | — | — | 1 | 5.11 |
| CHEMBL1762349 | — | — | 1 | 5.06 |
| CHEMBL1762350 | — | — | 1 | 5.04 |
| CHEMBL1762365 | — | — | 1 | 5.04 |
| CHEMBL456798 | — | — | 1 | 5.00 |
| CHEMBL1762363 | — | — | 1 | 4.87 |
| CHEMBL1762351 | — | — | 1 | - |
| CHEMBL1762347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478081 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1762357 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1762356 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL1762354 | — | IC50 | = | 747.0 | nM | 6.13 |
| CHEMBL1762360 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1762358 | — | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL1762355 | — | IC50 | = | 1012.0 | nM | 6.00 |
| CHEMBL1762359 | — | IC50 | = | 1165.0 | nM | 5.93 |
| CHEMBL1762348 | — | IC50 | = | 2987.0 | nM | 5.53 |
| CHEMBL1762364 | — | IC50 | = | 3475.0 | nM | 5.46 |
| CHEMBL456799 | — | IC50 | = | 4425.0 | nM | 5.35 |
| CHEMBL1762366 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1762346 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL1762353 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1762361 | — | IC50 | = | 6950.0 | nM | 5.16 |
| CHEMBL1762352 | — | IC50 | = | 7666.0 | nM | 5.12 |
| CHEMBL1762362 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL1762349 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL1762350 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1762365 | — | IC50 | = | 9125.0 | nM | 5.04 |
| CHEMBL456798 | — | IC50 | = | 9967.0 | nM | 5.00 |
| CHEMBL1762363 | — | IC50 | = | 13450.0 | nM | 4.87 |
| CHEMBL1762351 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1762347 | — | IC50 | > | 10000.0 | nM | - |