Assay Detail
Functional
CHEMBL1767485
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Agonist activity at P2Y4 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.71 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1767409 | — | — | 1 | 7.64 |
| CHEMBL1767408 | DIQUAFOSOL TETRASODIUM | 4.0 | 1 | 6.40 |
| CHEMBL1767407 | DENUFOSOL TETRASODIUM | 3.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1767409 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1767408 | DIQUAFOSOL TETRASODIUM | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1767407 | DENUFOSOL TETRASODIUM | EC50 | = | 800.0 | nM | 6.10 |