Assay Detail
Binding
CHEMBL1767553
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Displacement of [3H]CP55940 from CB1 receptor
21
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.95 | 8.85 |
| IC50 | 1 | 9.15 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226591 | — | — | 1 | 9.15 |
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 8.85 |
| CHEMBL1765684 | — | — | 1 | 7.80 |
| CHEMBL1765820 | — | — | 1 | 7.26 |
| CHEMBL1765683 | — | — | 1 | 7.21 |
| CHEMBL1765682 | — | — | 1 | 6.94 |
| CHEMBL1765679 | — | — | 1 | 6.59 |
| CHEMBL1765672 | — | — | 1 | 6.53 |
| CHEMBL1765819 | — | — | 1 | 6.45 |
| CHEMBL1765677 | — | — | 1 | 6.36 |
| CHEMBL1765681 | — | — | 1 | 6.30 |
| CHEMBL1765685 | — | — | 1 | 6.17 |
| CHEMBL1765673 | — | — | 1 | - |
| CHEMBL1765674 | — | — | 1 | - |
| CHEMBL1765096 | — | — | 1 | - |
| CHEMBL1765675 | — | — | 1 | - |
| CHEMBL1765676 | — | — | 1 | - |
| CHEMBL1765678 | — | — | 1 | - |
| CHEMBL1765680 | — | — | 1 | - |
| CHEMBL1765818 | — | — | 1 | - |
| CHEMBL1765821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226591 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL111 | RIMONABANT | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1765684 | — | Ki | = | 15.7 | nM | 7.80 |
| CHEMBL1765820 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL1765683 | — | Ki | = | 62.2 | nM | 7.21 |
| CHEMBL1765682 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL1765679 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL1765672 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL1765819 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL1765677 | — | Ki | = | 437.0 | nM | 6.36 |
| CHEMBL1765681 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL1765685 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL1765673 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1765674 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1765096 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1765675 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1765676 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1765678 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1765680 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1765818 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1765821 | — | Ki | > | 10000.0 | nM | - |