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Assay Detail

CHEMBL1767574

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine recombinant eNOS expressed in Escherichia coli by UV-vis spectrometric analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Nitric oxide synthase 3 (CHEMBL4802)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.
Xue F, Fang J, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB.
J Med Chem (2011) 54 : 2039 -2048
PubMed 21410186 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.38 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1766633 1 5.85
CHEMBL1766629 1 5.82
CHEMBL1766628 1 5.76
CHEMBL1766631 1 5.62
CHEMBL1615288 1 5.57
CHEMBL1615287 1 5.38
CHEMBL1615292 1 5.30
CHEMBL1615290 1 5.03
CHEMBL1615289 1 4.79
CHEMBL1615291 1 4.70
CHEMBL1766634 1 -
CHEMBL1766632 1 -
CHEMBL1766630 1 -
CHEMBL1766627 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1766633 Ki = 1410.0 nM 5.85
CHEMBL1766629 Ki = 1520.0 nM 5.82
CHEMBL1766628 Ki = 1740.0 nM 5.76
CHEMBL1766631 Ki = 2390.0 nM 5.62
CHEMBL1615288 Ki = 2680.0 nM 5.57
CHEMBL1615287 Ki = 4200.0 nM 5.38
CHEMBL1615292 Ki = 4950.0 nM 5.30
CHEMBL1615290 Ki = 9400.0 nM 5.03
CHEMBL1615289 Ki = 16100.0 nM 4.79
CHEMBL1615291 Ki = 20000.0 nM 4.70
CHEMBL1766634 Ki - -
CHEMBL1766632 Ki - -
CHEMBL1766630 Ki - -
CHEMBL1766627 Ki - -