Assay Detail
Binding
CHEMBL1767592
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Inhibition of human Pgp overexpressed in human MDCK2-MDR1 cells assessed as inhibition of R123 efflux after 60 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK-II |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Radiosynthesis and in vivo evaluation of 1-[18F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.91 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396298 | ELACRIDAR | 2.0 | 1 | 6.40 |
| CHEMBL1765143 | — | — | 1 | 6.22 |
| CHEMBL1765142 | — | — | 1 | 5.85 |
| CHEMBL1765141 | — | — | 1 | 5.80 |
| CHEMBL1765140 | — | — | 1 | 5.77 |
| CHEMBL1765139 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396298 | ELACRIDAR | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1765143 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1765142 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1765141 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1765140 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1765139 | — | IC50 | = | 3800.0 | nM | 5.42 |