Assay Detail
Binding
CHEMBL1767685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATR in human HT-29 cells assessed as hydroxyurea-induced phosphorylation of H2AX by immunofluorescence microscopy
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.81 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766798 | — | — | 1 | 6.42 |
| CHEMBL1766797 | — | — | 1 | 6.38 |
| CHEMBL1766799 | — | — | 1 | 6.34 |
| CHEMBL1766786 | — | — | 1 | 6.00 |
| CHEMBL1766793 | — | — | 1 | 6.00 |
| CHEMBL1766796 | — | — | 1 | 6.00 |
| CHEMBL1766788 | — | — | 1 | 5.85 |
| CHEMBL1766792 | — | — | 1 | 5.82 |
| CHEMBL1766795 | — | — | 1 | 5.80 |
| CHEMBL1766787 | — | — | 1 | 5.70 |
| CHEMBL1766794 | — | — | 1 | 5.70 |
| CHEMBL1766791 | — | — | 1 | 5.27 |
| CHEMBL1766789 | — | — | 1 | 5.19 |
| CHEMBL1766790 | — | — | 1 | 4.92 |
| CHEMBL1766784 | — | — | 1 | - |
| CHEMBL1766785 | — | — | 1 | - |
| CHEMBL1766759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766798 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1766797 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1766799 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1766786 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1766793 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1766796 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1766788 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1766792 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1766795 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1766787 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1766794 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1766791 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1766789 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1766790 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1766784 | — | IC50 | - | — | - | |
| CHEMBL1766785 | — | IC50 | - | — | - | |
| CHEMBL1766759 | — | IC50 | > | 2500.0 | nM | - |