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Assay Detail

CHEMBL1767792

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NCI/ADR-RES cells after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI/ADR-RES
Confidence 1 — Organism
Curated By Autocuration

Target

NCI/ADR-RES (CHEMBL613829)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs).
Yamada R, Cao X, Butkevich AN, Millard M, Odde S, Mordwinkin N, Gundla R, Zandi E, Louie SG, Petasis NA, Neamati N.
J Med Chem (2011) 54 : 2902 -2914
PubMed 21443194 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.26 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1766682 1 6.70
CHEMBL1363219 1 6.52
CHEMBL1766690 1 6.52
CHEMBL1766687 1 6.52
CHEMBL1766684 1 6.52
CHEMBL1610049 1 6.52
CHEMBL1766681 1 6.52
CHEMBL1766689 1 6.40
CHEMBL1766695 1 6.40
CHEMBL1766688 1 6.40
CHEMBL1462900 1 6.40
CHEMBL1766692 1 6.16
CHEMBL1621541 1 6.05
CHEMBL1766683 1 6.00
CHEMBL1766685 1 6.00
CHEMBL1766686 1 5.92
CHEMBL1766694 1 5.89
CHEMBL1766691 1 5.89
CHEMBL1766693 1 5.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1766682 IC50 = 200.0 nM 6.70
CHEMBL1363219 IC50 = 300.0 nM 6.52
CHEMBL1766690 IC50 = 300.0 nM 6.52
CHEMBL1766687 IC50 = 300.0 nM 6.52
CHEMBL1766684 IC50 = 300.0 nM 6.52
CHEMBL1610049 IC50 = 300.0 nM 6.52
CHEMBL1766681 IC50 = 300.0 nM 6.52
CHEMBL1766689 IC50 = 400.0 nM 6.40
CHEMBL1766695 IC50 = 400.0 nM 6.40
CHEMBL1766688 IC50 = 400.0 nM 6.40
CHEMBL1462900 IC50 = 400.0 nM 6.40
CHEMBL1766692 IC50 = 700.0 nM 6.16
CHEMBL1621541 IC50 = 900.0 nM 6.05
CHEMBL1766683 IC50 = 1000.0 nM 6.00
CHEMBL1766685 IC50 = 1000.0 nM 6.00
CHEMBL1766686 IC50 = 1200.0 nM 5.92
CHEMBL1766694 IC50 = 1300.0 nM 5.89
CHEMBL1766691 IC50 = 1300.0 nM 5.89
CHEMBL1766693 IC50 = 2200.0 nM 5.66