Assay Detail
Binding
CHEMBL1767947
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Inhibition of human Cdc25A
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Using small molecules to target protein phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.01 | 7.66 |
| Ki | 1 | 7.54 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429095 | — | — | 1 | 7.66 |
| CHEMBL337173 | — | — | 1 | 7.54 |
| CHEMBL1765351 | — | — | 1 | 6.60 |
| CHEMBL1765356 | — | — | 1 | 6.36 |
| CHEMBL1765355 | — | — | 1 | 6.10 |
| CHEMBL459929 | — | — | 1 | 6.10 |
| CHEMBL1165659 | — | — | 1 | 6.00 |
| CHEMBL1765352 | — | — | 1 | 5.70 |
| CHEMBL1765354 | — | — | 1 | 5.29 |
| CHEMBL228419 | — | — | 1 | 5.29 |
| CHEMBL1765353 | DYSIDIOLIDE | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429095 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL337173 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1765351 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1765356 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1765355 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL459929 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1165659 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1765352 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1765354 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL228419 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1765353 | DYSIDIOLIDE | IC50 | = | 9400.0 | nM | 5.03 |