Assay Detail
Binding
CHEMBL1767951
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Inhibition of SHP-2
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Using small molecules to target protein phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.05 | 6.50 |
| Ki | 1 | 6.16 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501993 | — | — | 1 | 6.50 |
| CHEMBL1765357 | — | — | 1 | 6.16 |
| CHEMBL472003 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501993 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1765357 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL472003 | — | IC50 | = | 2500.0 | nM | 5.60 |