Assay Detail
Binding
CHEMBL1767986
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Inhibition of human DGAT1 expressed in CHO-K1 cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 6.25 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766888 | — | — | 1 | 7.03 |
| CHEMBL1766886 | — | — | 1 | 6.86 |
| CHEMBL1766892 | — | — | 1 | 6.78 |
| CHEMBL1766893 | — | — | 1 | 6.72 |
| CHEMBL1766887 | — | — | 1 | 6.67 |
| CHEMBL1766812 | — | — | 1 | 6.66 |
| CHEMBL1766891 | — | — | 1 | 6.66 |
| CHEMBL1766882 | — | — | 1 | 6.64 |
| CHEMBL1766810 | — | — | 1 | 6.44 |
| CHEMBL1766805 | — | — | 1 | 6.44 |
| CHEMBL1766806 | — | — | 1 | 6.43 |
| CHEMBL1766890 | — | — | 1 | 6.42 |
| CHEMBL1766889 | — | — | 1 | 6.39 |
| CHEMBL1766811 | — | — | 1 | 6.31 |
| CHEMBL1766816 | — | — | 1 | 6.27 |
| CHEMBL1766813 | — | — | 1 | 6.18 |
| CHEMBL1766809 | — | — | 1 | 5.97 |
| CHEMBL473967 | — | — | 1 | 5.84 |
| CHEMBL1766807 | — | — | 1 | 5.75 |
| CHEMBL1766817 | — | — | 1 | 5.74 |
| CHEMBL1766808 | — | — | 1 | 5.63 |
| CHEMBL1766883 | — | — | 1 | 5.25 |
| CHEMBL1766884 | — | — | 1 | 4.60 |
| CHEMBL1766885 | — | — | 1 | - |
| CHEMBL1766815 | — | — | 1 | - |
| CHEMBL1766814 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766888 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1766886 | — | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL1766892 | — | EC50 | = | 165.0 | nM | 6.78 |
| CHEMBL1766893 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1766887 | — | EC50 | = | 216.0 | nM | 6.67 |
| CHEMBL1766812 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1766891 | — | EC50 | = | 219.0 | nM | 6.66 |
| CHEMBL1766882 | — | EC50 | = | 228.0 | nM | 6.64 |
| CHEMBL1766810 | — | EC50 | = | 365.0 | nM | 6.44 |
| CHEMBL1766805 | — | EC50 | = | 362.0 | nM | 6.44 |
| CHEMBL1766806 | — | EC50 | = | 371.0 | nM | 6.43 |
| CHEMBL1766890 | — | EC50 | = | 378.0 | nM | 6.42 |
| CHEMBL1766889 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1766811 | — | EC50 | = | 493.0 | nM | 6.31 |
| CHEMBL1766816 | — | EC50 | = | 534.0 | nM | 6.27 |
| CHEMBL1766813 | — | EC50 | = | 661.0 | nM | 6.18 |
| CHEMBL1766809 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL473967 | — | EC50 | = | 1436.0 | nM | 5.84 |
| CHEMBL1766807 | — | EC50 | = | 1764.0 | nM | 5.75 |
| CHEMBL1766817 | — | EC50 | = | 1803.0 | nM | 5.74 |
| CHEMBL1766808 | — | EC50 | = | 2363.0 | nM | 5.63 |
| CHEMBL1766883 | — | EC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL1766884 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1766885 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL1766815 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL1766814 | — | EC50 | > | 25000.0 | nM | - |