Assay Detail
Binding
CHEMBL1767987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DGAT1 expressed in baculovirus infected insect cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.90 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766884 | — | — | 1 | 7.80 |
| CHEMBL1766887 | — | — | 1 | 7.55 |
| CHEMBL1766807 | — | — | 1 | 7.46 |
| CHEMBL1766813 | — | — | 1 | 7.42 |
| CHEMBL1766888 | — | — | 1 | 7.39 |
| CHEMBL1766816 | — | — | 1 | 7.32 |
| CHEMBL1766811 | — | — | 1 | 7.24 |
| CHEMBL1766886 | — | — | 1 | 7.23 |
| CHEMBL1766882 | — | — | 1 | 7.17 |
| CHEMBL1766805 | — | — | 1 | 7.17 |
| CHEMBL1766889 | — | — | 1 | 7.15 |
| CHEMBL1766810 | — | — | 1 | 7.11 |
| CHEMBL1766812 | — | — | 1 | 7.09 |
| CHEMBL1766806 | — | — | 1 | 7.08 |
| CHEMBL1766891 | — | — | 1 | 7.08 |
| CHEMBL473967 | — | — | 1 | 6.95 |
| CHEMBL1766890 | — | — | 1 | 6.89 |
| CHEMBL1766808 | — | — | 1 | 6.89 |
| CHEMBL1766892 | — | — | 1 | 6.87 |
| CHEMBL1766893 | — | — | 1 | 6.78 |
| CHEMBL1766885 | — | — | 1 | 6.70 |
| CHEMBL1766883 | — | — | 1 | 6.62 |
| CHEMBL1766809 | — | — | 1 | 6.56 |
| CHEMBL1766817 | — | — | 1 | 6.49 |
| CHEMBL1766814 | — | — | 1 | 4.82 |
| CHEMBL1766815 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766884 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1766887 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1766807 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1766813 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1766888 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1766816 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1766811 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1766886 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1766882 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1766805 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1766889 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1766810 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1766812 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1766806 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1766891 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL473967 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1766890 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL1766808 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL1766892 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL1766893 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL1766885 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL1766883 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL1766809 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL1766817 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL1766814 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL1766815 | — | IC50 | = | 24700.0 | nM | 4.61 |