Assay Detail
Binding
CHEMBL1768123
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IMPY from amyloid beta (1 to 42) aggregate after 2 hrs by gamma counting
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-affinity relationships of novel dibenzylideneacetone derivatives as probes for β-amyloid plaques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 70 | 8.16 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1767217 | — | — | 1 | 9.15 |
| CHEMBL1767222 | — | — | 1 | 9.10 |
| CHEMBL1767377 | — | — | 1 | 9.05 |
| CHEMBL1767215 | — | — | 1 | 9.05 |
| CHEMBL404678 | — | — | 1 | 9.00 |
| CHEMBL1767213 | — | — | 1 | 8.96 |
| CHEMBL1767211 | — | — | 1 | 8.92 |
| CHEMBL1767227 | — | — | 1 | 8.92 |
| CHEMBL1767223 | — | — | 1 | 8.89 |
| CHEMBL1767197 | — | — | 1 | 8.74 |
| CHEMBL1767228 | — | — | 1 | 8.72 |
| CHEMBL1767226 | — | — | 1 | 8.70 |
| CHEMBL1767188 | — | — | 1 | 8.66 |
| CHEMBL1767189 | — | — | 1 | 8.64 |
| CHEMBL1767199 | — | — | 1 | 8.60 |
| CHEMBL255168 | — | — | 1 | 8.57 |
| CHEMBL1767201 | — | — | 1 | 8.55 |
| CHEMBL1767214 | — | — | 1 | 8.55 |
| CHEMBL1767187 | — | — | 1 | 8.55 |
| CHEMBL1767387 | — | — | 1 | 8.55 |
| CHEMBL1767220 | — | — | 1 | 8.54 |
| CHEMBL1767212 | — | — | 1 | 8.43 |
| CHEMBL1767219 | — | — | 1 | 8.43 |
| CHEMBL1767185 | — | — | 1 | 8.42 |
| CHEMBL1767195 | — | — | 1 | 8.42 |
| CHEMBL1767384 | — | — | 1 | 8.40 |
| CHEMBL1767230 | — | — | 1 | 8.40 |
| CHEMBL1767183 | — | — | 1 | 8.39 |
| CHEMBL1767198 | — | — | 1 | 8.38 |
| CHEMBL1767203 | — | — | 1 | 8.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1767217 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1767222 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL1767215 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1767377 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL404678 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1767213 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1767211 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1767227 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1767223 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL1767197 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL1767228 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1767226 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1767188 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1767189 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL1767199 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL255168 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL1767201 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL1767214 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL1767187 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL1767387 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL1767220 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL1767212 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL1767219 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL1767185 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1767195 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1767384 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1767230 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1767183 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL1767198 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL1767203 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL1767386 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL1767190 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL1767218 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL1767194 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL1767388 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL1767385 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL1767229 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL1767202 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL1767192 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL584437 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL1767216 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL1767204 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL1767200 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1767233 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1767232 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL1767380 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL1767193 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL1767205 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL496321 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1767383 | — | Ki | = | 9.2 | nM | 8.04 |