Assay Detail
Binding
CHEMBL1768168
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Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Non-peptide NK1 receptor ligands based on the 4-phenylpyridine moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.05 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 8.82 |
| CHEMBL1765500 | — | — | 1 | 8.32 |
| CHEMBL281491 | — | — | 1 | 7.72 |
| CHEMBL1765494 | — | — | 1 | 7.50 |
| CHEMBL1765502 | — | — | 1 | 7.39 |
| CHEMBL25639 | — | — | 1 | 7.38 |
| CHEMBL1765499 | — | — | 1 | 7.28 |
| CHEMBL1765498 | — | — | 1 | 7.28 |
| CHEMBL1765506 | — | — | 1 | 7.28 |
| CHEMBL1765504 | — | — | 1 | 7.24 |
| CHEMBL413027 | — | — | 1 | 7.04 |
| CHEMBL1765496 | — | — | 1 | 7.04 |
| CHEMBL1765492 | — | — | 1 | 7.01 |
| CHEMBL24894 | — | — | 1 | 6.68 |
| CHEMBL277004 | — | — | 1 | 6.64 |
| CHEMBL1765497 | — | — | 1 | 6.63 |
| CHEMBL282853 | — | — | 1 | 6.59 |
| CHEMBL1765495 | — | — | 1 | 6.57 |
| CHEMBL1765503 | — | — | 1 | 6.55 |
| CHEMBL1765493 | — | — | 1 | 6.47 |
| CHEMBL1765501 | — | — | 1 | 6.36 |
| CHEMBL1765491 | — | — | 1 | 6.18 |
| CHEMBL1765505 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1765500 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL281491 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1765494 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1765502 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL25639 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1765499 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1765498 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1765506 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1765504 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL413027 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1765496 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL1765492 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL24894 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL277004 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL1765497 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL282853 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL1765495 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1765503 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL1765493 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL1765501 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL1765491 | — | IC50 | = | 653.0 | nM | 6.18 |
| CHEMBL1765505 | — | IC50 | = | 698.0 | nM | 6.16 |