Assay Detail
Binding
CHEMBL1768181
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Inhibition of chymotrypsin assessed as p-nitroaniline release measured for 15 mins using Bz-L-Tyr-pNA as a substrate by Dixon plot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.78 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | — | 1 | 4.89 |
| CHEMBL1765514 | — | — | 1 | 4.66 |
| CHEMBL1765509 | — | — | 1 | - |
| CHEMBL1765510 | — | — | 1 | - |
| CHEMBL1765511 | — | — | 1 | - |
| CHEMBL1765512 | — | — | 1 | - |
| CHEMBL1765513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL1765514 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL1765509 | — | Ki | - | — | - | |
| CHEMBL1765510 | — | Ki | - | — | - | |
| CHEMBL1765511 | — | Ki | = | 341000.0 | nM | - |
| CHEMBL1765512 | — | Ki | = | 255000.0 | nM | - |
| CHEMBL1765513 | — | Ki | = | 104000.0 | nM | - |