Assay Detail
Binding
CHEMBL1768320
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Inhibition of human recombinant COX-2 after 2 mins by fluorescence assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 8.00 |
| CHEMBL1766299 | — | — | 1 | 6.16 |
| CHEMBL1766288 | — | — | 1 | 6.05 |
| CHEMBL1766298 | — | — | 1 | 6.00 |
| CHEMBL1766295 | — | — | 1 | 6.00 |
| CHEMBL1766287 | — | — | 1 | 5.89 |
| CHEMBL1766297 | — | — | 1 | 5.70 |
| CHEMBL1766285 | — | — | 1 | 5.70 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 5.70 |
| CHEMBL1766294 | — | — | 1 | 5.60 |
| CHEMBL1766301 | — | — | 1 | 5.55 |
| CHEMBL1766300 | — | — | 1 | 5.52 |
| CHEMBL1766286 | — | — | 1 | 5.22 |
| CHEMBL1766292 | — | — | 1 | 5.16 |
| CHEMBL1766284 | — | — | 1 | 5.16 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.77 |
| CHEMBL1766293 | — | — | 1 | - |
| CHEMBL1766296 | — | — | 1 | - |
| CHEMBL1766291 | — | — | 1 | - |
| CHEMBL1766290 | — | — | 1 | - |
| CHEMBL1766289 | — | — | 1 | - |
| CHEMBL1766302 | — | — | 1 | - |
| CHEMBL1766283 | — | — | 1 | - |
| CHEMBL242459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1766299 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1766288 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1766298 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1766295 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1766287 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1766297 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1766285 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1766294 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1766301 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1766300 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1766286 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1766292 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1766284 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1766293 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1766296 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1766291 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1766290 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1766289 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1766302 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1766283 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL242459 | — | IC50 | > | 100000.0 | nM | - |