Assay Detail
Binding
CHEMBL1768321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.10 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766284 | — | — | 1 | 9.30 |
| CHEMBL242459 | — | — | 1 | 9.30 |
| CHEMBL1766285 | — | — | 1 | 9.30 |
| CHEMBL1766288 | — | — | 1 | 9.30 |
| CHEMBL1766283 | — | — | 1 | 9.10 |
| CHEMBL1766286 | — | — | 1 | 9.10 |
| CHEMBL1766287 | — | — | 1 | 9.05 |
| CHEMBL1766290 | — | — | 1 | 8.59 |
| CHEMBL1766300 | — | — | 1 | 8.47 |
| CHEMBL1766299 | — | — | 1 | 8.39 |
| CHEMBL1766292 | — | — | 1 | 8.22 |
| CHEMBL1766301 | — | — | 1 | 8.00 |
| CHEMBL1766289 | — | — | 1 | 7.60 |
| CHEMBL1766298 | — | — | 1 | 7.58 |
| CHEMBL1766296 | — | — | 1 | 7.50 |
| CHEMBL1766291 | — | — | 1 | 7.33 |
| CHEMBL1766294 | — | — | 1 | 7.14 |
| CHEMBL1766295 | — | — | 1 | 7.08 |
| CHEMBL1766297 | — | — | 1 | 7.06 |
| CHEMBL1766293 | — | — | 1 | 6.96 |
| CHEMBL1766302 | — | — | 1 | 5.81 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766284 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL242459 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1766285 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1766288 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1766283 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1766286 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1766287 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1766290 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1766300 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1766299 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1766292 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1766301 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1766289 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1766298 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1766296 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1766291 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1766294 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1766295 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1766297 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1766293 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1766302 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL118 | CELECOXIB | IC50 | > | 1000.0 | nM | - |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 1000.0 | nM | - |
| CHEMBL122 | ROFECOXIB | IC50 | > | 1000.0 | nM | - |