Assay Detail
Binding
CHEMBL1768362
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP11B2 expressed in hamster V79 MZh cells assessed as conversion of [4-14C]-11-deoxycorticosterone substrate by HPTLC assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79 MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 8.54 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765214 | — | — | 1 | 9.70 |
| CHEMBL1765215 | — | — | 1 | 9.70 |
| CHEMBL1765207 | — | — | 1 | 9.22 |
| CHEMBL1765220 | — | — | 1 | 9.15 |
| CHEMBL1765222 | — | — | 1 | 9.05 |
| CHEMBL1765208 | — | — | 1 | 9.05 |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 9.00 |
| CHEMBL1765209 | — | — | 1 | 9.00 |
| CHEMBL1765205 | — | — | 1 | 8.96 |
| CHEMBL1765232 | — | — | 1 | 8.92 |
| CHEMBL1765229 | — | — | 1 | 8.92 |
| CHEMBL1765219 | — | — | 1 | 8.89 |
| CHEMBL1765228 | — | — | 1 | 8.85 |
| CHEMBL1765221 | — | — | 1 | 8.85 |
| CHEMBL1765210 | — | — | 1 | 8.66 |
| CHEMBL1765224 | — | — | 1 | 8.64 |
| CHEMBL1765226 | — | — | 1 | 8.62 |
| CHEMBL1765206 | — | — | 1 | 8.62 |
| CHEMBL446083 | — | — | 1 | 8.59 |
| CHEMBL1765223 | — | — | 1 | 8.44 |
| CHEMBL1765211 | — | — | 1 | 8.37 |
| CHEMBL1765212 | — | — | 1 | 8.36 |
| CHEMBL1765227 | — | — | 1 | 8.34 |
| CHEMBL1765213 | — | — | 1 | 8.23 |
| CHEMBL1765230 | — | — | 1 | 7.80 |
| CHEMBL1765225 | — | — | 1 | 7.75 |
| CHEMBL457425 | — | — | 1 | 7.66 |
| CHEMBL62811 | — | — | 1 | 7.55 |
| CHEMBL1765231 | — | — | 1 | 7.48 |
| CHEMBL1765217 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765214 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1765215 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1765207 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1765220 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1765222 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1765208 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1765209 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1765205 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1765232 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1765229 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1765219 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1765228 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1765221 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1765210 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1765224 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1765226 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1765206 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL446083 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1765223 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1765211 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1765212 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1765227 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1765213 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1765230 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1765225 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL457425 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL62811 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1765231 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1765217 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1765218 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1765216 | — | IC50 | - | — | - | |
| CHEMBL1765233 | — | IC50 | - | — | - |