Assay Detail
Binding
CHEMBL1768394
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Displacement of [3H]spiperone from wild type human dopamine D3 receptor expressed in HEK293 cells after 60 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.96 | 10.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765633 | — | — | 1 | 10.12 |
| CHEMBL112065 | — | — | 1 | 9.05 |
| CHEMBL1765638 | — | — | 1 | 9.00 |
| CHEMBL1765637 | — | — | 1 | 8.57 |
| CHEMBL1765634 | — | — | 1 | 7.72 |
| CHEMBL1765636 | — | — | 1 | 7.36 |
| CHEMBL193337 | — | — | 1 | 6.82 |
| CHEMBL1196271 | — | — | 1 | 6.64 |
| CHEMBL1765635 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765633 | — | Ki | = | 0.076 | nM | 10.12 |
| CHEMBL112065 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1765638 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1765637 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL1765634 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1765636 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL193337 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1196271 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL1765635 | — | Ki | = | 410.0 | nM | 6.39 |