Assay Detail
Binding
CHEMBL1768396
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Displacement of [3H]spiperone from human dopamine D3 receptor V2.61F mutant expressed in HEK293 cells after 60 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.40 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765633 | — | — | 1 | 6.77 |
| CHEMBL112065 | — | — | 1 | 6.75 |
| CHEMBL1765638 | — | — | 1 | 6.64 |
| CHEMBL1765637 | — | — | 1 | 6.60 |
| CHEMBL1765635 | — | — | 1 | 6.48 |
| CHEMBL1196271 | — | — | 1 | 6.46 |
| CHEMBL193337 | — | — | 1 | 6.38 |
| CHEMBL1765636 | — | — | 1 | 6.12 |
| CHEMBL1765634 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765633 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL112065 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL1765638 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL1765637 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1765635 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL1196271 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL193337 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL1765636 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL1765634 | — | Ki | = | 3700.0 | nM | 5.43 |