Assay Detail
Binding
CHEMBL1768398
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Displacement of [3H]spiperone from human dopamine D3 receptor S5.46A mutant expressed in HEK293 cells after 60 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.80 | 10.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765633 | — | — | 1 | 10.24 |
| CHEMBL112065 | — | — | 1 | 9.80 |
| CHEMBL1765634 | — | — | 1 | 7.82 |
| CHEMBL193337 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765633 | — | Ki | = | 0.058 | nM | 10.24 |
| CHEMBL112065 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL1765634 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL193337 | — | Ki | = | 45.0 | nM | 7.35 |