Assay Detail
Binding
CHEMBL1768404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-SRC
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.77 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195029 | — | — | 1 | 9.34 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 9.22 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 9.00 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 8.57 |
| CHEMBL571546 | TIRBANIBULIN | 4.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195029 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL571546 | TIRBANIBULIN | IC50 | = | 20.0 | nM | 7.70 |