Assay Detail
Binding
CHEMBL1768783
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDK1-mediated AKT phosphorylation at Thr308 residue in human PC3 cells by ELISA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
3-phosphoinositide-dependent protein kinase 1 (CHEMBL2534) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.08 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765750 | — | — | 1 | 8.05 |
| CHEMBL1765751 | — | — | 1 | 7.66 |
| CHEMBL1765743 | — | — | 1 | 7.62 |
| CHEMBL1765742 | — | — | 1 | 7.24 |
| CHEMBL1614777 | — | — | 1 | 7.13 |
| CHEMBL1765744 | — | — | 1 | 7.07 |
| CHEMBL1765740 | — | — | 1 | 6.95 |
| CHEMBL1765738 | — | — | 1 | 6.78 |
| CHEMBL1765741 | — | — | 1 | 6.58 |
| CHEMBL1614775 | — | — | 1 | 6.49 |
| CHEMBL1765739 | — | — | 1 | 6.33 |
| CHEMBL1765736 | — | — | 1 | - |
| CHEMBL1765737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765750 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1765751 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1765743 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1765742 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1614777 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1765744 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1765740 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1765738 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL1765741 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL1614775 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL1765739 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL1765736 | — | IC50 | > | 29300.0 | nM | - |
| CHEMBL1765737 | — | IC50 | - | — | - |