Assay Detail
Binding
CHEMBL1768947
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Inhibition of recombinant glucocerebrosidase in McIlvaine buffer at pH 7.4 after 10 mins by fluorometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.37 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766350 | — | — | 1 | 7.22 |
| CHEMBL1766482 | — | — | 1 | 7.00 |
| CHEMBL1766474 | — | — | 1 | 6.52 |
| CHEMBL408500 | — | — | 1 | 6.52 |
| CHEMBL1766489 | — | — | 1 | 5.89 |
| CHEMBL1766470 | — | — | 1 | 5.75 |
| CHEMBL1766473 | — | — | 1 | 5.72 |
| CHEMBL1083795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766350 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1766482 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1766474 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL408500 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1766489 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1766470 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1766473 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1083795 | — | IC50 | - | — | - |