Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1769015

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect sells assessed as hydrogen peroxide production by fluorimetric method
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BTI-TN-5B1-4
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.
Desideri N, Bolasco A, Fioravanti R, Monaco LP, Orallo F, Yáñez M, Ortuso F, Alcaro S.
J Med Chem (2011) 54 : 2155 -2164
PubMed 21405131 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 6.24 8.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL452001 1 8.07
CHEMBL1077616 1 8.06
CHEMBL1766551 1 7.88
CHEMBL972 SELEGILINE 4.0 1 7.71
CHEMBL1766550 1 7.50
CHEMBL1383041 1 7.26
CHEMBL511011 1 7.23
CHEMBL1766556 1 6.98
CHEMBL1766558 1 6.85
CHEMBL452004 1 6.81
CHEMBL1766619 1 6.62
CHEMBL451747 1 6.61
CHEMBL1766553 1 6.48
CHEMBL1766557 1 6.32
CHEMBL1766561 1 6.32
CHEMBL1766549 1 6.32
CHEMBL1766560 1 6.31
CHEMBL1766554 1 6.06
CHEMBL1766555 1 5.97
CHEMBL1766562 1 5.88
CHEMBL1766614 1 5.88
CHEMBL1766552 1 5.80
CHEMBL1766612 1 5.72
CHEMBL1766625 1 5.51
CHEMBL1766626 1 5.34
CHEMBL1766624 1 5.13
CHEMBL92401 IPRONIAZID 2.0 1 5.12
CHEMBL1766613 1 4.68
CHEMBL1766620 1 4.67
CHEMBL1766622 1 4.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL452001 IC50 = 8.51 nM 8.07
CHEMBL1077616 IC50 = 8.61 nM 8.06
CHEMBL1766551 IC50 = 13.03 nM 7.88
CHEMBL972 SELEGILINE IC50 = 19.6 nM 7.71
CHEMBL1766550 IC50 = 31.82 nM 7.50
CHEMBL1383041 IC50 = 55.37 nM 7.26
CHEMBL511011 IC50 = 58.9 nM 7.23
CHEMBL1766556 IC50 = 104.34 nM 6.98
CHEMBL1766558 IC50 = 140.52 nM 6.85
CHEMBL452004 IC50 = 154.23 nM 6.81
CHEMBL1766619 IC50 = 238.6 nM 6.62
CHEMBL451747 IC50 = 247.51 nM 6.61
CHEMBL1766553 IC50 = 331.11 nM 6.48
CHEMBL1766557 IC50 = 476.51 nM 6.32
CHEMBL1766549 IC50 = 479.7 nM 6.32
CHEMBL1766561 IC50 = 483.88 nM 6.32
CHEMBL1766560 IC50 = 490.84 nM 6.31
CHEMBL1766554 IC50 = 879.18 nM 6.06
CHEMBL1766555 IC50 = 1060.0 nM 5.97
CHEMBL1766562 IC50 = 1330.0 nM 5.88
CHEMBL1766614 IC50 = 1310.0 nM 5.88
CHEMBL1766552 IC50 = 1570.0 nM 5.80
CHEMBL1766612 IC50 = 1920.0 nM 5.72
CHEMBL1766625 IC50 = 3070.0 nM 5.51
CHEMBL1766626 IC50 = 4590.0 nM 5.34
CHEMBL1766624 IC50 = 7370.0 nM 5.13
CHEMBL92401 IPRONIAZID IC50 = 7540.0 nM 5.12
CHEMBL1766613 IC50 = 20690.0 nM 4.68
CHEMBL1766620 IC50 = 21590.0 nM 4.67
CHEMBL1766622 IC50 = 58530.0 nM 4.23
CHEMBL8706 CLORGILINE IC50 = 61350.0 nM 4.21