Assay Detail
Binding
CHEMBL1769016
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Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect sells assessed as hydrogen peroxide production by fluorimetric method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.19 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766561 | — | — | 1 | 5.84 |
| CHEMBL1766555 | — | — | 1 | 5.68 |
| CHEMBL1766558 | — | — | 1 | 5.32 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.18 |
| CHEMBL1077616 | — | — | 1 | 4.94 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 4.17 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766561 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL1766555 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1766558 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL1077616 | — | IC50 | = | 11460.0 | nM | 4.94 |
| CHEMBL972 | SELEGILINE | IC50 | = | 67250.0 | nM | 4.17 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 361000.0 | nM | - |
| CHEMBL8706 | CLORGILINE | IC50 | = | 4.46 | nM | - |