Assay Detail
Binding
CHEMBL1769066
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.10 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112065 | — | — | 1 | 6.24 |
| CHEMBL1765632 | — | — | 1 | 5.75 |
| CHEMBL1765630 | — | — | 1 | 5.44 |
| CHEMBL1765629 | — | — | 1 | 5.17 |
| CHEMBL1765631 | — | — | 1 | 4.64 |
| CHEMBL193337 | — | — | 1 | 4.28 |
| CHEMBL197159 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112065 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL1765632 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL1765630 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL1765629 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL1765631 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL193337 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL197159 | — | Ki | = | 68000.0 | nM | 4.17 |