Assay Detail
Binding
CHEMBL1769067
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Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.47 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765633 | — | — | 1 | 8.28 |
| CHEMBL112065 | — | — | 1 | 7.32 |
| CHEMBL1765630 | — | — | 1 | 7.00 |
| CHEMBL1765629 | — | — | 1 | 6.82 |
| CHEMBL1765632 | — | — | 1 | 6.57 |
| CHEMBL1765634 | — | — | 1 | 6.52 |
| CHEMBL193337 | — | — | 1 | 6.39 |
| CHEMBL1765631 | — | — | 1 | 5.08 |
| CHEMBL197159 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765633 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL112065 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL1765630 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1765629 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1765632 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL1765634 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL193337 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL1765631 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL197159 | — | Ki | = | 55000.0 | nM | 4.26 |