Assay Detail
Binding
CHEMBL1769070
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Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cells after 60 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.36 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112065 | — | — | 1 | 7.57 |
| CHEMBL1765629 | — | — | 1 | 7.23 |
| CHEMBL1765630 | — | — | 1 | 6.72 |
| CHEMBL1765632 | — | — | 1 | 6.64 |
| CHEMBL193337 | — | — | 1 | 6.42 |
| CHEMBL1765631 | — | — | 1 | 5.20 |
| CHEMBL197159 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112065 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1765629 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL1765630 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL1765632 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL193337 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL1765631 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL197159 | — | Ki | = | 17000.0 | nM | 4.77 |