Assay Detail
Binding
CHEMBL1769072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]7-OH-DPAT from human dopamine D2long receptor expressed in CHO cells after 60 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.22 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765633 | — | — | 1 | 9.00 |
| CHEMBL193337 | — | — | 1 | 8.34 |
| CHEMBL1765634 | — | — | 1 | 7.31 |
| CHEMBL197159 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765633 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL193337 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL1765634 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL197159 | — | Ki | = | 57000.0 | nM | 4.24 |