Assay Detail
Binding
CHEMBL1769430
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Displacement of [3H]Naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aminothiazolomorphinans with mixed κ and μ opioid activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.04 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | — | 1 | 8.72 |
| CHEMBL1766024 | — | — | 1 | 7.60 |
| CHEMBL1766032 | — | — | 1 | 7.54 |
| CHEMBL242756 | — | — | 1 | 7.54 |
| CHEMBL1766031 | — | — | 1 | 7.47 |
| CHEMBL1766030 | — | — | 1 | 7.39 |
| CHEMBL1766025 | — | — | 1 | 7.37 |
| CHEMBL1766039 | — | — | 1 | 7.33 |
| CHEMBL1766041 | — | — | 1 | 7.30 |
| CHEMBL1766022 | — | — | 1 | 7.27 |
| CHEMBL1766023 | — | — | 1 | 7.25 |
| CHEMBL1766036 | — | — | 1 | 7.19 |
| CHEMBL1766043 | — | — | 1 | 7.12 |
| CHEMBL1766027 | — | — | 1 | 7.10 |
| CHEMBL1766040 | — | — | 1 | 7.04 |
| CHEMBL1766044 | — | — | 1 | 6.92 |
| CHEMBL1766029 | — | — | 1 | 6.85 |
| CHEMBL1766033 | — | — | 1 | 6.82 |
| CHEMBL299220 | — | — | 1 | 6.82 |
| CHEMBL1766026 | — | — | 1 | 6.75 |
| CHEMBL1766021 | — | — | 1 | 6.72 |
| CHEMBL1766042 | — | — | 1 | 6.66 |
| CHEMBL390866 | — | — | 1 | 6.64 |
| CHEMBL1766045 | — | — | 1 | 6.38 |
| CHEMBL1766038 | — | — | 1 | 6.13 |
| CHEMBL1766028 | — | — | 1 | 6.12 |
| CHEMBL1766037 | — | — | 1 | 5.96 |
| CHEMBL1766035 | — | — | 1 | - |
| CHEMBL1766034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1766024 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL1766032 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL242756 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1766031 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL1766030 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL1766025 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL1766039 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL1766041 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1766022 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL1766023 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL1766036 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL1766043 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL1766027 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL1766040 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL1766044 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL1766029 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1766033 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL299220 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1766026 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL1766021 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL1766042 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL390866 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL1766045 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL1766038 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL1766028 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL1766037 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1766035 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1766034 | — | Ki | > | 10000.0 | nM | - |