Assay Detail
Binding
CHEMBL1769552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPDPE from human delta opioid receptor expressed in mouse HN9.10 cells
11
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.97 | 9.82 |
| IC50 | 5 | 8.72 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766207 | — | — | 2 | 9.82 |
| CHEMBL1766208 | — | — | 2 | 9.74 |
| CHEMBL1766205 | — | — | 2 | 9.34 |
| CHEMBL200199 | BIPHALIN | — | 1 | 8.59 |
| CHEMBL1766206 | — | — | 2 | 8.39 |
| CHEMBL1766204 | — | — | 2 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766207 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL1766208 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL1766207 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL1766208 | — | IC50 | = | 0.3802 | nM | 9.42 |
| CHEMBL1766205 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL1766205 | — | IC50 | = | 0.9772 | nM | 9.01 |
| CHEMBL200199 | BIPHALIN | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL1766206 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL1766206 | — | IC50 | = | 8.511 | nM | 8.07 |
| CHEMBL1766204 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1766204 | — | IC50 | = | 23.99 | nM | 7.62 |