Assay Detail
Binding
CHEMBL1769850
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Inhibition of influenza A virus neuraminidase assessed as cleavage of MUNANA substrate by fluorescence assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activity of thiazolidine-4-carboxylic acid derivatives as novel influenza neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.55 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 7.70 |
| CHEMBL1767361 | — | — | 1 | 6.85 |
| CHEMBL1765113 | — | — | 1 | 6.68 |
| CHEMBL1767358 | — | — | 1 | 6.55 |
| CHEMBL1767357 | — | — | 1 | 6.28 |
| CHEMBL1767351 | — | — | 1 | 6.19 |
| CHEMBL1767359 | — | — | 1 | 6.09 |
| CHEMBL1767362 | — | — | 1 | 6.01 |
| CHEMBL1767360 | — | — | 1 | 5.99 |
| CHEMBL1767350 | — | — | 1 | 5.92 |
| CHEMBL1767355 | — | — | 1 | 5.79 |
| CHEMBL1767354 | — | — | 1 | 5.73 |
| CHEMBL1767352 | — | — | 1 | 5.72 |
| CHEMBL1767353 | — | — | 1 | 5.61 |
| CHEMBL1767356 | — | — | 1 | 5.54 |
| CHEMBL1767344 | — | — | 1 | 5.23 |
| CHEMBL1767347 | — | — | 1 | 5.12 |
| CHEMBL1767343 | — | — | 1 | 5.12 |
| CHEMBL1767348 | — | — | 1 | 5.10 |
| CHEMBL1767346 | — | — | 1 | 5.06 |
| CHEMBL1767345 | — | — | 1 | 4.97 |
| CHEMBL1767341 | — | — | 1 | 4.91 |
| CHEMBL1767349 | — | — | 1 | 4.89 |
| CHEMBL1767338 | — | — | 1 | 4.74 |
| CHEMBL1767337 | — | — | 1 | 4.70 |
| CHEMBL154191 | — | — | 1 | 4.67 |
| CHEMBL1767340 | — | — | 1 | 4.65 |
| CHEMBL1767339 | — | — | 1 | 4.63 |
| CHEMBL1767342 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1767361 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1765113 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1767358 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1767357 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1767351 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1767359 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1767362 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL1767360 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL1767350 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL1767355 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL1767354 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL1767352 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL1767353 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL1767356 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL1767344 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL1767347 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL1767343 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL1767348 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL1767346 | — | IC50 | = | 8640.0 | nM | 5.06 |
| CHEMBL1767345 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL1767341 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL1767349 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL1767338 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL1767337 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL154191 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL1767340 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL1767339 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL1767342 | — | IC50 | = | 43100.0 | nM | 4.37 |