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Assay Detail

CHEMBL1771845

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human ERG
12
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Design of potent and selective GPR119 agonists for type II diabetes.
Szewczyk JW, Acton J, Adams AD, Chicchi G, Freeman S, Howard AD, Huang Y, Li C, Meinke PT, Mosely R, Murphy E, Samuel R, Santini C, Yang M, Zhang Y, Zhao K, Wood HB.
Bioorg Med Chem Lett (2011) 21 : 2665 -2669
PubMed 21273063 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.70 6.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1771093 1 6.56
CHEMBL1771099 2 5.92
CHEMBL1771097 2 5.82
CHEMBL1771094 1 5.75
CHEMBL1771098 3 5.58
CHEMBL1771095 1 5.27
CHEMBL1771096 1 4.97
CHEMBL1771104 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1771093 IC50 = 277.0 nM 6.56
CHEMBL1771099 IC50 = 1200.0 nM 5.92
CHEMBL1771097 IC50 = 1500.0 nM 5.82
CHEMBL1771094 IC50 = 1800.0 nM 5.75
CHEMBL1771097 IC50 = 1900.0 nM 5.72
CHEMBL1771098 IC50 = 2600.0 nM 5.58
CHEMBL1771095 IC50 = 5400.0 nM 5.27
CHEMBL1771096 IC50 = 10600.0 nM 4.97
CHEMBL1771098 IC50 > 30000.0 nM -
CHEMBL1771098 IC50 > 30000.0 nM -
CHEMBL1771099 IC50 > 30000.0 nM -
CHEMBL1771104 IC50 > 30000.0 nM -