Assay Detail
Binding
CHEMBL1772002
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Inhibition of Francisella tularensis N-terminal hexahistidine-tagged arabinose phosphate isomerase expressed in Escherichia coli BL21(DE3) after 3 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Francisella tularensis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Arabinose 5-phosphate isomerase KdsD (CHEMBL1770042) ↗| Type | SINGLE PROTEIN |
| Organism | Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) |
Publication
Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.87 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114269 | — | — | 1 | 5.16 |
| CHEMBL323922 | — | — | 1 | 5.00 |
| CHEMBL116018 | — | — | 1 | 4.46 |
| CHEMBL324609 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114269 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL323922 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL116018 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL324609 | — | IC50 | = | 3000000.0 | nM | - |