Assay Detail
Binding
CHEMBL1772151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]histamine from human histamine H4 receptor
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 7.76 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1770975 | — | — | 1 | 10.40 |
| CHEMBL1770971 | — | — | 1 | 9.70 |
| CHEMBL1770968 | — | — | 1 | 9.52 |
| CHEMBL1770973 | — | — | 1 | 9.05 |
| CHEMBL1770992 | — | — | 1 | 9.00 |
| CHEMBL1771001 | — | — | 1 | 9.00 |
| CHEMBL1771000 | — | — | 1 | 8.70 |
| CHEMBL1770964 | — | — | 1 | 8.70 |
| CHEMBL1770998 | — | — | 1 | 8.52 |
| CHEMBL1770966 | — | — | 1 | 8.52 |
| CHEMBL1770969 | — | — | 1 | 8.52 |
| CHEMBL1770977 | — | — | 1 | 8.52 |
| CHEMBL1770979 | — | — | 1 | 8.40 |
| CHEMBL129198 | JNJ-7777120 | — | 1 | 8.40 |
| CHEMBL1770959 | — | — | 1 | 8.22 |
| CHEMBL1770990 | — | — | 1 | 8.22 |
| CHEMBL505061 | — | — | 1 | 8.22 |
| CHEMBL1770160 | — | — | 1 | 8.10 |
| CHEMBL1770980 | — | — | 1 | 8.05 |
| CHEMBL1770987 | — | — | 1 | 8.00 |
| CHEMBL1770985 | — | — | 1 | 7.82 |
| CHEMBL492677 | — | — | 1 | 7.70 |
| CHEMBL1770999 | — | — | 1 | 7.62 |
| CHEMBL1770976 | — | — | 1 | 7.60 |
| CHEMBL185951 | — | — | 1 | 7.58 |
| CHEMBL1770962 | — | — | 1 | 7.55 |
| CHEMBL1770970 | — | — | 1 | 7.54 |
| CHEMBL1770995 | — | — | 1 | 7.44 |
| CHEMBL1770997 | — | — | 1 | 7.40 |
| CHEMBL1770982 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1770975 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL1770971 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1770968 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL1770973 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1770992 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1771001 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1771000 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1770964 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1770998 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1770966 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1770969 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1770977 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL129198 | JNJ-7777120 | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1770979 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL505061 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1770959 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1770990 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1770160 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1770980 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1770987 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1770985 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL492677 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1770999 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1770976 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL185951 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL1770962 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1770970 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1770995 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL1770997 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL1770982 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL1770974 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1770978 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL1770981 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL1770994 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL1770960 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL1770972 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL1770996 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL1770965 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1770993 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL1770986 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL1770991 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1770967 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL1770983 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL1770963 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL1770961 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL1770984 | — | Ki | = | 853.0 | nM | 6.07 |
| CHEMBL1770988 | — | Ki | = | 1076.0 | nM | 5.97 |
| CHEMBL1770989 | — | Ki | = | 1155.0 | nM | 5.94 |