Assay Detail
Functional
CHEMBL1772152
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Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.33 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1770966 | — | — | 1 | 7.96 |
| CHEMBL1770998 | — | — | 1 | 7.92 |
| CHEMBL1770987 | — | — | 1 | 7.80 |
| CHEMBL1770964 | — | — | 1 | 7.30 |
| CHEMBL1770985 | — | — | 1 | 7.07 |
| CHEMBL1771001 | — | — | 1 | 7.00 |
| CHEMBL1770962 | — | — | 1 | 6.27 |
| CHEMBL505061 | — | — | 1 | - |
| CHEMBL1770994 | — | — | 1 | - |
| CHEMBL1770995 | — | — | 1 | - |
| CHEMBL1770996 | — | — | 1 | - |
| CHEMBL1770997 | — | — | 1 | - |
| CHEMBL1770999 | — | — | 1 | - |
| CHEMBL1771000 | — | — | 1 | - |
| CHEMBL1770977 | — | — | 1 | - |
| CHEMBL1770979 | — | — | 1 | - |
| CHEMBL1770980 | — | — | 1 | - |
| CHEMBL1770990 | — | — | 1 | - |
| CHEMBL1770992 | — | — | 1 | - |
| CHEMBL1770959 | — | — | 1 | - |
| CHEMBL1770965 | — | — | 1 | - |
| CHEMBL1770969 | — | — | 1 | - |
| CHEMBL1770971 | — | — | 1 | - |
| CHEMBL1770972 | — | — | 1 | - |
| CHEMBL1770160 | — | — | 1 | - |
| CHEMBL1770973 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1770966 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1770998 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1770987 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1770964 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1770985 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1771001 | — | EC50 | = | 101.0 | nM | 7.00 |
| CHEMBL1770962 | — | EC50 | = | 533.0 | nM | 6.27 |
| CHEMBL505061 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770994 | — | EC50 | - | — | - | |
| CHEMBL1770995 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770996 | — | EC50 | - | — | - | |
| CHEMBL1770997 | — | EC50 | - | — | - | |
| CHEMBL1770999 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1771000 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770977 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770979 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770980 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770990 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770992 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770959 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770965 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770969 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770971 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770972 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770160 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1770973 | — | EC50 | > | 10000.0 | nM | - |