Assay Detail
Binding
CHEMBL1772168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]BTA-1 from amyloid beta 1 to 40 by competitive binding assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2-Arylimidazo[2,1-b]benzothiazoles: a new family of amyloid binding agents with potential for PET and SPECT imaging of Alzheimer's brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.66 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 1 | 8.35 |
| CHEMBL1672898 | — | — | 1 | 8.21 |
| CHEMBL599472 | — | — | 1 | 8.05 |
| CHEMBL1771173 | — | — | 1 | 8.03 |
| CHEMBL1771169 | — | — | 1 | 7.96 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | 2.0 | 1 | 7.96 |
| CHEMBL78012 | — | — | 1 | 7.82 |
| CHEMBL1771172 | — | — | 1 | 7.75 |
| CHEMBL1771171 | — | — | 1 | 7.68 |
| CHEMBL1771174 | — | — | 1 | 7.58 |
| CHEMBL1771166 | — | — | 1 | 7.54 |
| CHEMBL1672895 | — | — | 1 | 7.53 |
| CHEMBL1771167 | — | — | 1 | 7.46 |
| CHEMBL1771164 | — | — | 1 | 7.42 |
| CHEMBL1771170 | — | — | 1 | 7.38 |
| CHEMBL1771165 | — | — | 1 | 7.37 |
| CHEMBL1771168 | — | — | 1 | 7.36 |
| CHEMBL1672890 | — | — | 1 | 7.23 |
| CHEMBL1771163 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL1672898 | — | Ki | = | 6.09 | nM | 8.21 |
| CHEMBL599472 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1771173 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL1771169 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL78012 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1771172 | — | Ki | = | 17.7 | nM | 7.75 |
| CHEMBL1771171 | — | Ki | = | 21.1 | nM | 7.68 |
| CHEMBL1771174 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL1771166 | — | Ki | = | 28.8 | nM | 7.54 |
| CHEMBL1672895 | — | Ki | = | 29.8 | nM | 7.53 |
| CHEMBL1771167 | — | Ki | = | 34.5 | nM | 7.46 |
| CHEMBL1771164 | — | Ki | = | 38.1 | nM | 7.42 |
| CHEMBL1771170 | — | Ki | = | 41.9 | nM | 7.38 |
| CHEMBL1771165 | — | Ki | = | 42.9 | nM | 7.37 |
| CHEMBL1771168 | — | Ki | = | 43.4 | nM | 7.36 |
| CHEMBL1672890 | — | Ki | = | 58.6 | nM | 7.23 |
| CHEMBL1771163 | — | Ki | = | 133.0 | nM | 6.88 |