Assay Detail
Binding
CHEMBL1772418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on gamma secretase-mediated notch processing in C57BL/6 mouse fetal thymic organ cultures assessed as reduction of B and T-cell populations after 45 mins by FACS analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: discovery of PF-3084014.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.54 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1770915 | — | — | 1 | 5.96 |
| CHEMBL1770916 | NIROGACESTAT | 4.0 | 1 | 5.74 |
| CHEMBL1770912 | — | — | 1 | 5.59 |
| CHEMBL1770914 | — | — | 1 | 5.52 |
| CHEMBL1770911 | — | — | 1 | 5.49 |
| CHEMBL1770917 | — | — | 1 | 5.29 |
| CHEMBL1770913 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1770915 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL1770916 | NIROGACESTAT | EC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL1770912 | — | EC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL1770914 | — | EC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL1770911 | — | EC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL1770917 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1770913 | — | EC50 | = | 6100.0 | nM | 5.21 |