Assay Detail
Functional
CHEMBL1772471
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Antiproliferative activity against mouse L1210 cells assessed as inhibition of cell growth after 48 hrs by ZF-Coulter Counting
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.11 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379867 | — | — | 1 | 7.92 |
| CHEMBL1771630 | — | — | 1 | 6.80 |
| CHEMBL1771628 | — | — | 1 | 6.68 |
| CHEMBL1771629 | — | — | 1 | 6.35 |
| CHEMBL1771735 | — | — | 1 | 6.28 |
| CHEMBL1771627 | — | — | 1 | 6.28 |
| CHEMBL212734 | — | — | 1 | 5.89 |
| CHEMBL1771631 | — | — | 1 | 5.64 |
| CHEMBL1771731 | — | — | 1 | 5.58 |
| CHEMBL1771732 | — | — | 1 | 5.52 |
| CHEMBL1771636 | — | — | 1 | 5.30 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.07 |
| CHEMBL1771632 | — | — | 1 | - |
| CHEMBL1771633 | — | — | 1 | - |
| CHEMBL1771634 | — | — | 1 | - |
| CHEMBL1771635 | — | — | 1 | - |
| CHEMBL1771734 | — | — | 1 | - |
| CHEMBL1771733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379867 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1771630 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1771628 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1771629 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1771735 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1771627 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL212734 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1771631 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1771731 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1771732 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1771636 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL852 | MELPHALAN | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1771632 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1771633 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1771634 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1771635 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1771734 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1771733 | — | IC50 | > | 10000.0 | nM | - |