Assay Detail
Functional
CHEMBL1772543
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Cytotoxicity against human HT-29 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Semisynthesis of triptolide analogues: effect of γ-lactone and C-14 substituents on cytotoxic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.80 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1771407 | — | — | 1 | 9.19 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.12 |
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 8.68 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.23 |
| CHEMBL205190 | TRIPTONIDE | — | 1 | 8.08 |
| CHEMBL1771405 | — | — | 1 | 7.66 |
| CHEMBL1771400 | — | — | 1 | 7.11 |
| CHEMBL1771406 | — | — | 1 | 6.41 |
| CHEMBL1771401 | — | — | 1 | 5.70 |
| CHEMBL1771402 | — | — | 1 | - |
| CHEMBL1771403 | — | — | 1 | - |
| CHEMBL1771404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1771407 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL205190 | TRIPTONIDE | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL1771405 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1771400 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1771406 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1771401 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL1771402 | — | IC50 | > | 13400.0 | nM | - |
| CHEMBL1771403 | — | IC50 | > | 13400.0 | nM | - |
| CHEMBL1771404 | — | IC50 | > | 13400.0 | nM | - |