Assay Detail
Binding
CHEMBL1772808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of telomerase activity expressed in human SGC7901 cells by SYBER green dye based TRAP
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | SGC-7901 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of N-phenylacetyl (sulfonyl) 4,5-dihydropyrazole derivatives as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.94 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.58 |
| CHEMBL1770486 | — | — | 1 | 5.40 |
| CHEMBL1770490 | — | — | 1 | 5.02 |
| CHEMBL1770495 | — | — | 1 | 4.90 |
| CHEMBL1770494 | — | — | 1 | 4.78 |
| CHEMBL1770493 | — | — | 1 | 4.76 |
| CHEMBL1770488 | — | — | 1 | 4.61 |
| CHEMBL1770487 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1770486 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1770490 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1770495 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1770494 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL1770493 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL1770488 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL1770487 | — | IC50 | = | 31500.0 | nM | 4.50 |