Assay Detail
Binding
CHEMBL1775258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IKK2 using 5-FAM-GRHDSGLDSMK-NH2 as substrate by TR-FRET assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.56 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360077 | — | — | 1 | 6.82 |
| CHEMBL1773329 | — | — | 1 | 6.04 |
| CHEMBL1773334 | — | — | 1 | 5.89 |
| CHEMBL1773327 | — | — | 1 | 5.68 |
| CHEMBL1773328 | — | — | 1 | 5.66 |
| CHEMBL1775219 | — | — | 1 | 5.50 |
| CHEMBL1773335 | — | — | 1 | 5.50 |
| CHEMBL1775231 | — | — | 1 | 5.43 |
| CHEMBL1773336 | — | — | 1 | 5.42 |
| CHEMBL1775233 | — | — | 1 | 5.42 |
| CHEMBL1773333 | — | — | 1 | 5.37 |
| CHEMBL1773330 | — | — | 1 | 5.25 |
| CHEMBL1773331 | — | — | 1 | 5.15 |
| CHEMBL1773326 | — | — | 1 | 4.71 |
| CHEMBL1775224 | — | — | 1 | - |
| CHEMBL1775225 | — | — | 1 | - |
| CHEMBL1775226 | — | — | 1 | - |
| CHEMBL1775227 | — | — | 1 | - |
| CHEMBL1775228 | — | — | 1 | - |
| CHEMBL1775229 | — | — | 1 | - |
| CHEMBL1775230 | — | — | 1 | - |
| CHEMBL1775232 | — | — | 1 | - |
| CHEMBL1775234 | — | — | 1 | - |
| CHEMBL1775235 | — | — | 1 | - |
| CHEMBL1775237 | — | — | 1 | - |
| CHEMBL1775238 | — | — | 1 | - |
| CHEMBL1775236 | — | — | 1 | - |
| CHEMBL1775239 | — | — | 1 | - |
| CHEMBL1773325 | — | — | 1 | - |
| CHEMBL1773332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360077 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1773329 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1773334 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1773327 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL1773328 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1775219 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1773335 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL1775231 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL1773336 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL1775233 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1773333 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL1773330 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1773331 | — | IC50 | = | 7020.0 | nM | 5.15 |
| CHEMBL1773326 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL1775220 | — | IC50 | - | — | - | |
| CHEMBL1775221 | — | IC50 | - | — | - | |
| CHEMBL1775222 | — | IC50 | - | — | - | |
| CHEMBL1775223 | — | IC50 | - | — | - | |
| CHEMBL1775224 | — | IC50 | - | — | - | |
| CHEMBL1775225 | — | IC50 | - | — | - | |
| CHEMBL1775226 | — | IC50 | - | — | - | |
| CHEMBL1775227 | — | IC50 | - | — | - | |
| CHEMBL1775228 | — | IC50 | - | — | - | |
| CHEMBL1775229 | — | IC50 | - | — | - | |
| CHEMBL1775230 | — | IC50 | - | — | - | |
| CHEMBL1775232 | — | IC50 | - | — | - | |
| CHEMBL1775234 | — | IC50 | - | — | - | |
| CHEMBL1775235 | — | IC50 | - | — | - | |
| CHEMBL1775237 | — | IC50 | - | — | - | |
| CHEMBL1775238 | — | IC50 | - | — | - | |
| CHEMBL1775236 | — | IC50 | - | — | - | |
| CHEMBL1775239 | — | IC50 | - | — | - | |
| CHEMBL1773325 | — | IC50 | - | — | - | |
| CHEMBL1773332 | — | IC50 | - | — | - |