Assay Detail
Binding
CHEMBL1775350
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Inhibition of wild-type Staphylococcus aureus topoisomerase 4-mediated decatenation of kDNA after 30 mins by gel electrophoresis assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.63 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774147 | — | — | 1 | 7.40 |
| CHEMBL1774264 | — | — | 1 | 7.22 |
| CHEMBL1774153 | — | — | 1 | 6.96 |
| CHEMBL1256993 | — | — | 1 | 6.92 |
| CHEMBL430 | GEMIFLOXACIN | 4.0 | 1 | 6.40 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 6.00 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774147 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1774264 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1774153 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1256993 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL430 | GEMIFLOXACIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 3000.0 | nM | 5.52 |