Assay Detail
Functional
CHEMBL1775392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.80 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1773261 | — | — | 1 | 7.46 |
| CHEMBL207881 | GW9508 | — | 1 | 7.06 |
| CHEMBL1688465 | — | — | 1 | 6.58 |
| CHEMBL1688452 | BENZYLOXYPHENYLPROPANOIC ACID | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1773261 | — | EC50 | = | 34.67 | nM | 7.46 |
| CHEMBL207881 | GW9508 | EC50 | = | 87.1 | nM | 7.06 |
| CHEMBL1688465 | — | EC50 | = | 263.03 | nM | 6.58 |
| CHEMBL1688452 | BENZYLOXYPHENYLPROPANOIC ACID | EC50 | = | 831.76 | nM | 6.08 |