Assay Detail
Binding
CHEMBL1775563
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Inhibition of clostridium botulinum Botulinum neurotoxin type A light chain at 20 uM
15
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium botulinum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Botulinum neurotoxin type A (CHEMBL5192) ↗| Type | SINGLE PROTEIN |
| Organism | Clostridium botulinum |
Publication
A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 13 | - | - |
| Ki | 2 | 5.08 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1773155 | — | — | 2 | 5.09 |
| CHEMBL1773156 | — | — | 2 | 5.06 |
| CHEMBL1773161 | — | — | 1 | - |
| CHEMBL1773159 | — | — | 1 | - |
| CHEMBL1773164 | — | — | 1 | - |
| CHEMBL1773162 | — | — | 1 | - |
| CHEMBL1773165 | — | — | 1 | - |
| CHEMBL1773158 | — | — | 1 | - |
| CHEMBL1773073 | — | — | 1 | - |
| CHEMBL1773163 | — | — | 1 | - |
| CHEMBL1773160 | — | — | 1 | - |
| CHEMBL1773157 | — | — | 1 | - |
| CHEMBL1773154 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1773155 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL1773156 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL1773161 | — | Inhibition | = | 73.5 | % | - |
| CHEMBL1773159 | — | Inhibition | = | 64.7 | % | - |
| CHEMBL1773164 | — | Inhibition | = | 63.4 | % | - |
| CHEMBL1773162 | — | Inhibition | = | 60.3 | % | - |
| CHEMBL1773165 | — | Inhibition | = | 55.6 | % | - |
| CHEMBL1773158 | — | Inhibition | = | 57.0 | % | - |
| CHEMBL1773155 | — | Inhibition | = | 70.0 | % | - |
| CHEMBL1773073 | — | Inhibition | = | 39.0 | % | - |
| CHEMBL1773163 | — | Inhibition | = | 66.1 | % | - |
| CHEMBL1773160 | — | Inhibition | = | 55.4 | % | - |
| CHEMBL1773157 | — | Inhibition | = | 68.9 | % | - |
| CHEMBL1773154 | — | Inhibition | = | 72.23 | % | - |
| CHEMBL1773156 | — | Inhibition | = | 62.7 | % | - |