Assay Detail
Binding
CHEMBL1775631
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IMPY from amyloid beta (1 to 42) after 3 hrs by gamma counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel 18F-labeled benzofuran derivatives with improved properties for positron emission tomography (PET) imaging of β-amyloid plaques in Alzheimer's brains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.46 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774456 | — | — | 1 | 9.02 |
| CHEMBL1774457 | — | — | 1 | 8.70 |
| CHEMBL1774454 | — | — | 1 | 8.62 |
| CHEMBL1774455 | — | — | 1 | 8.41 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 1 | 8.05 |
| CHEMBL78012 | — | — | 1 | 7.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774456 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL1774457 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1774454 | — | Ki | = | 2.41 | nM | 8.62 |
| CHEMBL1774455 | — | Ki | = | 3.85 | nM | 8.41 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL78012 | — | Ki | = | 10.5 | nM | 7.98 |