Assay Detail
Binding
CHEMBL1776016
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Displacement of [3H]Spiperone from human dopamine D2L receptor expressed in CHO cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of PF-00217830: aryl piperazine napthyridinones as D2 partial agonists for schizophrenia and bipolar disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 8.79 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774079 | — | — | 1 | 9.15 |
| CHEMBL1774080 | PF-00217830 | 2.0 | 1 | 9.09 |
| CHEMBL1774063 | — | — | 1 | 9.00 |
| CHEMBL1774064 | — | — | 1 | 9.00 |
| CHEMBL1774085 | — | — | 1 | 9.00 |
| CHEMBL1774066 | — | — | 1 | 9.00 |
| CHEMBL1774069 | — | — | 1 | 9.00 |
| CHEMBL1774078 | — | — | 1 | 9.00 |
| CHEMBL1774073 | — | — | 1 | 9.00 |
| CHEMBL1774074 | — | — | 1 | 9.00 |
| CHEMBL1774076 | — | — | 1 | 9.00 |
| CHEMBL1774082 | — | — | 1 | 8.96 |
| CHEMBL1774086 | — | — | 1 | 8.92 |
| CHEMBL1774077 | — | — | 1 | 8.85 |
| CHEMBL1774081 | — | — | 1 | 8.80 |
| CHEMBL1774087 | — | — | 1 | 8.77 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 8.74 |
| CHEMBL1774083 | — | — | 1 | 8.70 |
| CHEMBL1774065 | — | — | 1 | 8.70 |
| CHEMBL1774071 | — | — | 1 | 8.60 |
| CHEMBL1774068 | — | — | 1 | 8.60 |
| CHEMBL1774062 | — | — | 1 | 8.59 |
| CHEMBL1774075 | — | — | 1 | 8.52 |
| CHEMBL1774072 | — | — | 1 | 8.52 |
| CHEMBL1774070 | — | — | 1 | 8.30 |
| CHEMBL1774067 | — | — | 1 | 8.24 |
| CHEMBL1774084 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774079 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL1774080 | PF-00217830 | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL1774063 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1774064 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1774085 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1774066 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1774069 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1774078 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1774073 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1774074 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1774076 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1774082 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1774086 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1774077 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1774081 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL1774087 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL1774083 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1774065 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1774071 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1774068 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1774062 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL1774075 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1774072 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1774070 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1774067 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL1774084 | — | Ki | = | 6.0 | nM | 8.22 |