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Assay Detail

CHEMBL1776446

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense.
Gachet MS, Kunert O, Kaiser M, Brun R, Zehl M, Keller W, Muñoz RA, Bauer R, Schuehly W.
J Nat Prod (2011) 74 : 559 -566
PubMed 21438586 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.60 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 6.66
CHEMBL1775012 CUPACINOSIDE 1 5.89
CHEMBL1775013 1 5.68
CHEMBL469284 BETULONE 1 5.52
CHEMBL486393 LUPENONE 1 5.33
CHEMBL511822 TARAXEROL 1 5.07
CHEMBL1775014 CUPACINOXEPIN 1 5.06
CHEMBL71851 SCOPOLETIN 1 -
CHEMBL399036 1 -
CHEMBL1775015 1 -
CHEMBL1775016 1 -
CHEMBL470650 LICHEXANTHONE 1 -
CHEMBL481267 GUSTASTATIN 1 -
CHEMBL1775017 1 -
CHEMBL519077 TARAXERONE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 220.0 nM 6.66
CHEMBL1775012 CUPACINOSIDE IC50 = 1300.0 nM 5.89
CHEMBL1775013 IC50 = 2100.0 nM 5.68
CHEMBL469284 BETULONE IC50 = 3000.0 nM 5.52
CHEMBL486393 LUPENONE IC50 = 4700.0 nM 5.33
CHEMBL511822 TARAXEROL IC50 = 8500.0 nM 5.07
CHEMBL1775014 CUPACINOXEPIN IC50 = 8700.0 nM 5.06
CHEMBL71851 SCOPOLETIN IC50 > 25000.0 nM -
CHEMBL399036 IC50 > 25000.0 nM -
CHEMBL1775015 IC50 > 20000.0 nM -
CHEMBL1775016 IC50 > 20000.0 nM -
CHEMBL470650 LICHEXANTHONE IC50 > 20000.0 nM -
CHEMBL481267 GUSTASTATIN IC50 > 9000.0 nM -
CHEMBL1775017 IC50 > 10000.0 nM -
CHEMBL519077 TARAXERONE IC50 > 10000.0 nM -